Some regional prescribing information and facts also notes that temazepam could possibly be useful for premedication just before insignificant surgical treatment or other similar treatments 12.
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acute slim angle glaucoma (condition during which fluid stress in eye increases leading to problems of optic nerve)
Stay clear of or substitute Yet another drug for these prescription drugs when possible. Evaluate for lack of therapeutic outcome if medication have to be coadministered. Modify dose In accordance with prescribing information and facts if essential.
aprepitant will enhance the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Voxelotor improves systemic publicity of sensitive CYP3A4 substrates. Steer clear of coadministration with sensitive CYP3A4 substrates with a slender therapeutic index. Look at dose reduction from the sensitive CYP3A4 substrate(s) if unable to prevent.
metronidazole will enhance the stage or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Lencapavir (a reasonable CYP3A4 inhibitor) could improve CYP3A4 substrates initiated within 9 months immediately after previous SC dose of lenacapavir, which can enhance possible danger of adverse reactions of CYP3A4 substrates.
Administration of benzodiazepines or other prescription drugs that increase GABAergic inhibition to neonatal rats is reported to result in prevalent apoptotic neurodegeneration in the developing brain at plasma concentrations relevant for seizure Manage in human beings The window of vulnerability to those adjustments in rats (postnatal times 0-fourteen) includes a duration of Mind growth that normally takes put during the third trimester of pregnancy in people
sage decreases outcomes of diazepam by pharmacodynamic antagonism. Insignificant/Significance Unknown. Theoretical interaction; some species of sage might bring about convulsions.
The prescriber needs to be convinced from historic stories and/or personal observations that the affected individual exhibits identifiable traits of seizure cluster that could be distinguished within website the individual’s normal seizure action via the caregiver who'll be accountable for administering diazepam rectal gel
Temazepam is precisely indicated just for the quick-term administration of sleeplessness Label, twelve. In addition, these types of management is generally predominantly connected to the symptomatic aid of transient and short-term insomnia characterised by difficulty in slipping asleep, Repeated nocturnal awakenings and/or early morning awakenings 13. Particularly, the official prescribing details for temazepam normally specifies the Guidance issued for dispensed prescriptions on the medication really should point out specially that sufferers are only predicted to utilize the therapy for brief periods of time - usually seven-ten days normally Label,thirteen.
diazepam will improve the level or result of ruxolitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
griseofulvin will reduce the level or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.